Background: IGF- 1R is a transmembrane receptor belongs to class of tyrosine kinase receptors, found in many tumors and is often associated with an aggressive phenotype. IGF-1R is important for regulation of growth, differentiation and apoptosis, as such, could be a pre¬ferred target for therapeutic interventions. Aim: Investigate the expression pattern of IGF-1R in different histological grades of cutaneous and mucocutaneous squamous cell carcinoma and correlate with clinicopathological prognostic factors. Materials: Forty-eight specimens of cSCC were stained immunohistochemically with IGF-1R monoclonal antibody and correlated with different clinicopathologic factors. Results: All tumors showed a degree of positivity of IGF-1R cytoplasmic and membranous expression, however; with variable degrees. High grade tumors had significantly higher IGF-1R expression than low grade tumors. IGF-1R expression showed a strong positive correlation with the tumor grade (P<0.001). Also, IGF-1R expression showed a significant relation with the depth of invasion of SCC (P<0.001). Conclusion: IGF-1R expression is significantly associated with high grade in cutaneous and mucocutaneous squamous cell carcinoma and also associated with tumors showing deeper invasion; therefore, IGF-1R may have a role pathogenesis and progression of cutaneous and mucocutaneous squamous cell carcinoma.