Abstract Operational reports indicate that a spike of H2S is sometimes evolved while flowing back the acidizing treatment. H2S is produced by the reactions between acid and sulfide scales. We investigate in this paper the performance of various H2S scavengers and deliver guidelines for field application of H2S scavengers in acid treatment of wells. Five commercial H2S scavengers from chemical suppliers and service companies are evaluated under various conditions such as temperatures, acid-mineral ratios, and scavenger concentrations. Scavenger effects on reaction kinetics, acid dissolution capacity and scavenging capacity are investigated. Core flow tests, sequential spending tests, scavenger performance tests under field conditions, and compatibility tests were also performed to study scavenger effectiveness at various operation conditions and potential formation damage caused by spent scavengers. In the tests reported here we identify one product that meets all our performance criteria, several that meet most performance criteria and several that meet few of our performance criteria for potential application to scavenge H2S in well acidizing fluids.