Currently, TB is the most common opportunistic infection in individuals with HIV. Meanwhile, diabetes mellitus is a factor that can increase the risk of TB by 2-3 times. The aim of this study to investigate the relationship between Type 2 Diabetes Mellitus and HIV infection in suspected TB patients. The research design employed was an Analytical Observational study using a Cross-Sectional Study. Data were collected from blood sugar level tests and HIV antibody tests conducted on 40 suspected TB patients. The research was conducted from February to April 2024 at Cisadea Public Health Center in Malang City. Correlation analysis was performed using the Chi-Square test with a significance level of 95%. The Asymp Sig (2-sided) value for blood sugar levels in relation to TB examination results was 0.011, a significant relationship and value for HIV antibody test in relation to TB examination results was 0.708, thus suggesting no significant relationship.