Overview of the neurokinin-1 receptor antagonists

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2017Publisher:AME Publishing CompanyJournal:Biotarget, volume 1, pages 8-8 (eissn: 2522-669X,

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Authors: Rudolph M. Navari;

doi: 10.21037/biotarget.2017.06.01

Overview of the neurokinin-1 receptor antagonists

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Abstract

Neurokinin-1 (NK-1) receptor antagonists block substance P-mediated NK-1 receptors which are present in the abdominal vagus, the brainstem, and the area postrema in the brainstem. Substance P is a mammalian tachykinin that is found in vagal afferent neurons innervating the brainstem and sends impulses to the vomiting center (1). Compounds that block NK-1 receptors lessen emesis after cisplatin, ipecac, apomorphine, and radiation therapy (1).

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