Technological advances within the last two decades vastly increased options to restore damaged or diseased tissues and organs with viable replacements. Techniques to harvest, generate and implant them continue to evolve. Specialized knowledge, expertise and facilities make it possible to restore tissue function previously only imagined within current memory. Unfortunately, there are constraints on the total distance between donor and the recipient. This is due to fixed windows of time for tissue survival between harvest and implantation. The maximum allowable time reduces the transport distance to somewhat local versus global. Mechanisms to improve tissue and organ preservation will precipitously increase the potential recipient pool and reduce loss of invaluable tissue donations.