The Federal Ministry of Health and Pharmaceutical Fund and Supply Agency (PFSA) in collaboration with development partners have been implementing electronic Logistic Management Information System (eLMIS) – Health Commodity Management Information System (HCMIS), Facility Edition (FE) in more than 800 public health hospitals and health centers. The system is designed to support inventory control, and logistics management information system. The need for continuous improvement to fulfill evolving needs and the system’s ability to match the growth in increased commodity through puts will continue to be a challenge. In addition, data contained within eLMIS HCMIS is occasionally unreliable, inconsistent, or incomplete; and data are not used routinely enough for decisionmaking. Last but not least, the system is not linked in real-time to the HCMIS Warehouse (Warehouse Management System at PFSA), so real-time data visibility at the facility level is still a challenge due to internet access and reliability. The purpose of this study is to assess effectiveness of the e-LMIS implementation to optimize pharmaceutical management practices and enhance efficiency at hospitals and health centers under Addis Ababa Regional Health Bureau. Data was collected from sample of 39 users out of 49 mature e-LMIS HCMIS implementing public health facilities in Addis Ababa