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Acta Médica Portuguesa
Article . 2018 . Peer-reviewed
Data sources: Crossref
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Acta Médica Portuguesa
Article
License: CC BY NC ND
Data sources: UnpayWall
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https://doaj.org/article/7f319...
Article . 2018
Data sources: DOAJ
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Hipotiroidismo Subclínico no Idoso

Subclinical Hypothyroidism on the Elderly
Authors: Macedo Silva, S; Carvalho, A; Lopes-Pereira, M; Fernandes, V;

Hipotiroidismo Subclínico no Idoso

Abstract

Introdução: O hipotiroidismo subclínico, definido como um aumento da hormona estimulante da tiróide com níveis normais de hormonas tiroideias, poderá ter um impacto multiorgânico. No idoso (acima de 65 anos) parece haver diferenças que corroboram uma abordagem diagnóstica e terapêutica distintas.Material e Métodos: Revisão bibliográfica através das bases de dados eletrónicas.Resultados: Foram apresentados diferentes estudos que demonstram as consequências multiorgânicas do hipotiroidismo subclínico no idoso e que sugerem um impacto menor ou até ausente nesta população, principalmente acima dos 80 - 85 anos. Adicionalmente, estudos evidenciam que os valores de hormona estimulante da tiróide aumentam à medida que a idade avança. É consensual o início do tratamento com baixa dose de levotiroxina para valores de hormona estimulante da tiróide superiores a 10,0 mUI/L, presença de sintomas ou anticorpos anti-tiroideus positivos. O tratamento é discutível para hormona estimulante da tiróide entre 4,5 e 10,0 mUI/L, de tal forma que o estudo TRUST concluiu não haver benefícios no tratamento destes doentes.Discussão: A indefinição do intervalo de referência e da faixa etária são os fatores de enviesamento que mais dificultam a objetividade dos resultados. Todavia parece haver consenso em não tratar a disfunção tiroideia ligeira (4,5 - 7,0 mUI/L) no idoso, particularmente acima dos 80 anos. No entanto, se anticorpos anti-tiroideus positvos, alterações ecográficas sugestivas de tiroidite ou iatrogenia, deve ser considerado o limiar de 4,5 mUI/L.Conclusão: O impacto global do hipotiroidismo subclínico é diferente no idoso, pelo que uma abordagem terapêutica individualizada e monitorizada ao longo do tempo é a estratégia mais adequada.

Country
Portugal
Related Organizations
Keywords

Medicine (General), R5-920, Testes de Função Tiroideia, Idoso, R, Medicine, Valores de Referência, Hipotiroidismo/diagnóstico

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Published in a Diamond OA journal