Introduction. The pandemic derived from the presence of the SARS-CoV-2 virus, forced the population to adopt measures for biosecurity purposes, such as: healthy distance and confinement, the tasks that were normally carried out outside the home were temporarily stopped, triggering with this a series of stressors. Objective. The objective of this work was to analyze the relationship between physical activity and perceived academic stress during the SARS-CoV-2 pandemic in students of the Faculty of Medicine and Surgery of the Universidad Regional del Sureste. Methods. It was a descriptive-cross-sectional study, the sample was determined conveniently since the surveys were applied to second- and third-year students, through the Moodle platform of the advisor of this project, surveying 6 groups, the Cognitivist Systemic Inventory was applied to study academic stress (SISCO) and the International Physical Activity Questionnaire (IPAQ). Results. 84% refer to physical activity on a daily basis, in addition to the fact that 65.4% of students consider themselves to be under moderate stress, 16.6% do not present stress, 15.5% with mild stress and only 2.5% with severe stress, this perhaps derived from individual personalities and levels of self-demand. Conclusions. The main stressors are related to the self-directed study and the characteristics of the complementary activities of self-directed learning. The manifestations of stress are varied and of multifactorial origin, the most common being chronic fatigue, anxiety and headache. The practice of regular physical activity is related to greater physical and psycho-emotional well-being.