Powered by OpenAIRE graph
Found an issue? Give us feedback
addClaim

Excreción urinaria de uratos en niños y adolescentes obesos aquejados de Síndrome Metabólico

Authors: Rodríguez Peña, Yeidys; Santana Porbén, Sergio; Liriano Ricabal, María del Rosario; Salabarría González, José Reynaldo; Valdés Alonso, María del Carmen;

Excreción urinaria de uratos en niños y adolescentes obesos aquejados de Síndrome Metabólico

Abstract

Resumen Introducción El Síndrome metabólico (SM) asociado a la obesidad pediátrica se puede presentar con trastornos del metabolismo de las bases nitrogenadas que se trasladan hacia una excreción urinaria aumentada de uratos. Objetivos Describir el comportamiento de la excreción urinaria de uratos en niños y adolescentes obesos diagnosticados con SM. Diseño del estudio Analítico, de corte transversal. Serie de estudio Cincuenta y dos niños y adolescentes obesos atendidos en la consulta ambulatoria del Servicio de Endocrinología del Hospital “Juan Manuel Márquez”. Material y métodos La presencia del SM en los niños y adolescentes estudiados (Varones: 52,0%; Edad promedio: 11,4± 3,9 años) se identificó de la concurrencia de la circunferencia abdominal (CA) aumentadamás 1 (o más) de cualquiera de los siguientes factores de riesgo (FR): hipertensión arterial, Diabetes mellitus, y dislipidemias. De todos los casos se obtuvo el índice uratos/creatinina (mg/mg) en muestras matutinas de orina. La excreción urinaria de uratos (mg.24 horas-1) se estimó del índice uratos/creatinina después de ajustado según el sexo y la talla. La uricosuria de 24 horas así estimada, y los estados de hiperuricosuria (uricosuria 24 horas > punto de corte para la edad), se distribuyeron según la presencia del SM. Resultados El 34,6% de los niños se presentó con una (o más) manifestaciones del SM. La frecuencia de hiperuricosuria para toda la serie fue del 55,8%. Los niños con SM presentaron valores mayores de uricosuria (∆ = +56,8 mg. 24 horas-1; p > 0,05)y una mayor frecuencia de hiperuricosuria (∆ = +25,2%; p > 0,05). La frecuencia de hiperuricemia fue solo del 3,8%. Conclusiones EISM pudiera asociarse con una excreción aumentada de uratos.

Abstract Introduction Disorders of the metabolism of nitrogen bases eventually translating into an increased urine excretionof urates might be present in the Metabolic Syndrome (MS) associated with obesity Objectives To describe the behavior of urates urine excretion in obese children and adolescents diagnosed with MS Study design Analytical, cross-sectional. Study serie Fifty-two obese children and adolescents assisted at the Outpatient Clinic of the Endocrinology Service, “Juan Manuel Márquez” Pediatric Teaching Hospital (Havana city, Cuba). Material and method Presence of MS in the studied children and adolescents (Boys: 52.0%; Average age: 11.4 ± 3.9 years) was established from the concurrence of augmented abdominal circumference (CA) plus 1 (or more) of any of the followingrisk factors (RF): blood hypertension, Diabetes mellitus, and dyslipidemias. Urates/creatinine (mg/mg) index in urine morning samples was obtained in all cases. Urates urine excretion (mg. 24 hours-1) was estimated from the calculated urates/creatinine index after adjusting for sex andheight. 24 hours uricosuria values thus estimated, and hyperuricosuria states (24 hours uricosuria > cutoff point for age), were distributedaccording with MS presence. Results Thirty-four-point-six percent of the children presented with one (or more) manifestations of MS. Frequency of hyperuricosuria for the entire serie was 55.8%. Children with MS exhibited higher uricosuria values (∆ = +56.8 mg. 24 hours-1; p > 0.05) and a greater frequencyof hyperuricosuria (∆ = +25.2%; p > 0.05). Frequency of hyperuricemia was just 3.8%. Conclusions MS might be associated with an increasedurates excretion.

Keywords

Metabolic Syndrome, 24 hours uricosuria, Hiperuricosuria, Síndrome Metabólico, Uricosuria de 24 horas, Obesidad, Índice Uratos/Creatinina, Urates/Creatinine index, Hyperuricosuria

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!