
doi: 10.19230/jonnpr.3260
Resumen Introducción El Síndrome metabólico (SM) asociado a la obesidad pediátrica se puede presentar con trastornos del metabolismo de las bases nitrogenadas que se trasladan hacia una excreción urinaria aumentada de uratos. Objetivos Describir el comportamiento de la excreción urinaria de uratos en niños y adolescentes obesos diagnosticados con SM. Diseño del estudio Analítico, de corte transversal. Serie de estudio Cincuenta y dos niños y adolescentes obesos atendidos en la consulta ambulatoria del Servicio de Endocrinología del Hospital “Juan Manuel Márquez”. Material y métodos La presencia del SM en los niños y adolescentes estudiados (Varones: 52,0%; Edad promedio: 11,4± 3,9 años) se identificó de la concurrencia de la circunferencia abdominal (CA) aumentadamás 1 (o más) de cualquiera de los siguientes factores de riesgo (FR): hipertensión arterial, Diabetes mellitus, y dislipidemias. De todos los casos se obtuvo el índice uratos/creatinina (mg/mg) en muestras matutinas de orina. La excreción urinaria de uratos (mg.24 horas-1) se estimó del índice uratos/creatinina después de ajustado según el sexo y la talla. La uricosuria de 24 horas así estimada, y los estados de hiperuricosuria (uricosuria 24 horas > punto de corte para la edad), se distribuyeron según la presencia del SM. Resultados El 34,6% de los niños se presentó con una (o más) manifestaciones del SM. La frecuencia de hiperuricosuria para toda la serie fue del 55,8%. Los niños con SM presentaron valores mayores de uricosuria (∆ = +56,8 mg. 24 horas-1; p > 0,05)y una mayor frecuencia de hiperuricosuria (∆ = +25,2%; p > 0,05). La frecuencia de hiperuricemia fue solo del 3,8%. Conclusiones EISM pudiera asociarse con una excreción aumentada de uratos.
Abstract Introduction Disorders of the metabolism of nitrogen bases eventually translating into an increased urine excretionof urates might be present in the Metabolic Syndrome (MS) associated with obesity Objectives To describe the behavior of urates urine excretion in obese children and adolescents diagnosed with MS Study design Analytical, cross-sectional. Study serie Fifty-two obese children and adolescents assisted at the Outpatient Clinic of the Endocrinology Service, “Juan Manuel Márquez” Pediatric Teaching Hospital (Havana city, Cuba). Material and method Presence of MS in the studied children and adolescents (Boys: 52.0%; Average age: 11.4 ± 3.9 years) was established from the concurrence of augmented abdominal circumference (CA) plus 1 (or more) of any of the followingrisk factors (RF): blood hypertension, Diabetes mellitus, and dyslipidemias. Urates/creatinine (mg/mg) index in urine morning samples was obtained in all cases. Urates urine excretion (mg. 24 hours-1) was estimated from the calculated urates/creatinine index after adjusting for sex andheight. 24 hours uricosuria values thus estimated, and hyperuricosuria states (24 hours uricosuria > cutoff point for age), were distributedaccording with MS presence. Results Thirty-four-point-six percent of the children presented with one (or more) manifestations of MS. Frequency of hyperuricosuria for the entire serie was 55.8%. Children with MS exhibited higher uricosuria values (∆ = +56.8 mg. 24 hours-1; p > 0.05) and a greater frequencyof hyperuricosuria (∆ = +25.2%; p > 0.05). Frequency of hyperuricemia was just 3.8%. Conclusions MS might be associated with an increasedurates excretion.
Metabolic Syndrome, 24 hours uricosuria, Hiperuricosuria, Síndrome Metabólico, Uricosuria de 24 horas, Obesidad, Índice Uratos/Creatinina, Urates/Creatinine index, Hyperuricosuria
Metabolic Syndrome, 24 hours uricosuria, Hiperuricosuria, Síndrome Metabólico, Uricosuria de 24 horas, Obesidad, Índice Uratos/Creatinina, Urates/Creatinine index, Hyperuricosuria
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