Let <em>G </em>= (<em>V</em>(<em>G</em>),<em>E</em>(<em>G</em>)) be a graph and <em>k</em> be a positive integer. A total <em>k</em>-labeling of <em>G</em> is a map <em>f</em> : <em>V</em> ∪ <em>E</em> → {1,2,3,...,<em>k</em>}. The vertex weight <em>v</em> under the labeling <em>f</em> is denoted by w_<em>f</em>(<em>v</em>) and defined by <em>w</em>_<em>f</em>(<em>v</em>) = <em>f</em>(<em>v</em>) + \sum_{uv \in{E(G)}} {<em>f</em>(<em>uv</em>)}. A total <em>k</em>-labeling of <em>G</em> is called vertex irregular if there are no two vertices with the same weight. The total vertex irregularity strength of <em>G</em>, denoted by <em>tvs</em>(<em>G</em>), is the minimum <em>k</em> such that <em>G</em> has a vertex irregular total <em>k</em>-labeling. This labelings were introduced by Baca, Jendrol, Miller, and Ryan in 2007. Let <em>G</em> and <em>H</em> be two connected graphs. Let <em>o</em> be a vertex of <em>H</em>. The comb product between <em>G</em> and <em>H</em>, denoted by <em>G </em>\rhd_o <em>H</em>, is a graph obtained by taking one copy of <em>G</em> and |<em>V</em>(<em>G</em>)| copies of <em>H</em> and grafting the i-th copy of <em>H</em> at the vertex <em>o</em> to the i-th vertex of <em>G</em>. In this paper, we determine the total vertex irregularity strength of comb product of two cycles and two stars.