Anaplasmosis is a disease in dogs caused by gram-negative intracellular microorganisms belonging to the Anaplasmataceae family. A 1 year old Kintamani mix dog was examined at the Veterinary Hospital, Faculty of Veterinary Medicine, Udayana University with complaints; itching, tick infestation, weakness, decreased feeding and erythema throughout the dog's body. Clinical examination results show pale mucous membranes in the mouth, weak dogs, Riphicephalus tick infestation of the skin. Routine haematological examination revealed hyperchromic normocytic anemia and thrombocytopenia. Positive blood smear examination found Anaplasma spp. The therapy given is in the form of causative, symptomatic and supportive therapy. Causative therapy was given doxycycline dose 10 mg / kg BW given orally for 28 days, ivermectin dose 0.2-0.3 mg / kg BW, subcutaneously once a week for three weeks, symptomatic therapy with vetadryl dose 1-5 mg / kg BW, subcutaneosly once a week for three weeks, while supportive therapy was given by giving vitamin Livron b-plex once a day for 10 days. Treatment with doxycycline, ivermectin, vetadryl and livron b-plex gave good results in case dogs in terms of animal activity, hair growth, good appetite and free animals from ticks.