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Personalized medicine in internal medicine

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 10 May 2017Publisher:Medical Informational Agency PublishersJournal:Clinical Medicine (Russian Journal), volume 95, pages 197-200 (issn: 0023-2149, eissn: 2412-1339,

Authors: V.F. Marinin; D V Mandich; E V Shih; A B Prokofiev; M. V. Zhuravleva; G.V. Ramenskaya; A S Zhestovskaia; +6 Authors

doi: 10.18821/0023-2149-2017-95-3-197-200

pmid: 30303336

Personalized medicine in internal medicine

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Abstract

Personalized medicine - a new direction in medicine, which is based on the study of various biomarkers and the use of new methods of molecular analysis (primarily evaluating the activity of isoenzymes of cytochrome P450), allowing individualized approach to the selection of both the drugs and the selection of the dosing regimen for the purpose of maximize the effectiveness and safety of pharmacotherapy. This personalized medicine is to change the development and use of preventive and curative interventions. Genetic polymorphism isozymes of cytochrome P450 may determine the individual activity of a particular isozyme, and thus, to predict the clinical effectiveness, and in some cases, the risk of adverse reactions. The article is an example of the use of information on the activity of cytochrome P450 in clinical practice in matters of diagnosis, treatment and prevention of diseases. The scheme of the five best-known activity of isoenzymes of cytochrome P450 is shown.

Related Organizations

Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Sechenov University
Russian Federation

Keywords

Cytochrome P-450 Enzyme System, Medication Therapy Management, Pharmacogenetics, Internal Medicine, Humans, Precision Medicine

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