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https://dx.doi.org/10.18720/sp...

Other literature type . 2021

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descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2021 Russian Publisher:Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾

doi: 10.18720/spbpu/3/2021/vr/vr21-3686

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Abstract

This work is devoted to the primary screening of a number of drugs for antiviral activity against respiratory syncytial virus. The ED50 was measured using the sandwich ELISA method. Also, using the MTT test, the cytotoxicity (CTD50 value) of the drugs was measured. Based on the obtained values, the chemotherapeutic index (CTI) was calculated for each substance, from which the most promising compounds were subsequently selected. 93 substances were screened, of which 23 showed CTI acceptable for potential drugs. The highest CTI values were found in four substances - derivatives of berberine and borneols, which are planned to be investigated in the future as potential drugs against MS-viral infection.

Keywords

Ñ ÑÐ¾Ð¼ÐµÐ½Ñ, coumarins, ÐÐ¤Ð, ÐÐ¢Ð¢ ÑÐµÑÑ, ÐºÑÐ¼Ð°ÑÐ¸Ð½Ñ, ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾-ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½ÑÐ¹ Ð²Ð¸ÑÑÑ, respiratory syncytial virus, MTT test, Ñ Ð¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ Ð²Ð¸ÑÑÑÐ½ÑÑ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¹, berberines, Ð±ÐµÑÐ±ÐµÑÐ¸Ð½Ñ, ELISA, chemotherapy of viral infections, Ð±Ð¾ÑÐ½ÐµÐ¾Ð»Ñ, chromenes, borneols

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

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