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Роль адренорецепторов в Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸ÑÑ Ð»Ñ‘Ð³Ð¾Ñ‡Ð½Ð¾Ð¹ гемодинамики при экспериментальной ишемии миокарда

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Роль адренорецепторов в Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸ÑÑ Ð»Ñ‘Ð³Ð¾Ñ‡Ð½Ð¾Ð¹ гемодинамики при экспериментальной ишемии миокарда

Abstract

В работе рассматривается роль адренергических рецепторов в изменениях параметров легочной гемодинамики при экспериментальной миокардиальной ишемии у кроликов с альфа-адренергическими рецепторами, блокированными фентоламином, и бета-адренергическими рецепторами, блокированными пропранололом, и последующим сравнительным анализом. Были проведены две серии экспериментов. Вначале у животных вызывалась ишемия миокарда. После этого мы ждали стабилизации гемодинамических па-раметров. В первой серии животным вводили фентоламин в левую яремную вену, ишемия миокарда снова вызывалась. Во второй серии эксперимента животным вводили бета-адреноблокатор пропранолол. Исследование показало, что различия в изменениях параметров гемодинамики в легочной артерии во время экспериментальной миокардиальной ишемии определяются не только прямым влиянием блокады, но и изменениями других параметров, вызванными этой блокадой. Полученные результаты могут быть применены при выборе методов коррекции нарушений в работе системы кровообращения.

The given work is devoted to the study of the role of adrenergic receptors in changes of pulmonary hemodynamics parameters during experimental myocardial ischemia in rabbits with alpha-adrenergic receptors blocked by phentolamine and beta-adrenergic receptors blocked by propranolol and to the subsequent comparative analysis. Two series of experiments were conducted. In the beginning, myocardial ischemia was induced in animals. After this, we waited until the stabilization of hemodynamic parameters. In the first series, the animals were injected with phentolamine in the left jugular vein and myocardial ischemia was induced again. In the second series of the experiment, the animals were injected with the beta-blocker propranolol. The study found that the differences in changes of hemodynamic parameters in the pulmonary artery during experimental myocardial ischemia are determined not only by the direct influence of the blockade, but also by the changes in other parameters caused by this blockade. The results can be applied by choosing methods for correction of circulatory system disorders.

Keywords

лёгочная гемодинамика, адренорецепторы, фентоламин, ишемия миокарда, adrenoreceptors, pulmonary hemodynamics, alpha blockade, phentolamine, myocardial ischemia, альфа-блокада, бета-блокада, propranolol, пропранолол, beta blockade

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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