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Жизнеспособность и остеогенный потенциал ММСК костного мозга при росте на биоситалле «Биосит-СРЭлкор»

выпускная квалификационная работа магистра
descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2018 Russian Publisher:Санкт-Петербургский политехнический университет Петра Великого

doi: 10.18720/spbpu/2/v18-5209

Жизнеспособность и остеогенный потенциал ММСК костного мозга при росте на биоситалле «Биосит-СРЭлкор»

Abstract

Проведен анализ жизнеспособности и остеогенного потенциала ММСК костного мозга при росте на гранулах «Биосит-СРЭлкор». Показано, что микрочастицы, выкрашивающиеся из материала, негативно влияют на жизнеспособность ММСК. Исследованы способы очистки материала от микрочастиц. Оценено влияние покрытия гранул материала коллагеном I типа на жизнеспособность ММСК на биоситалле. Показано, что мезенхимные стромальные клетки хорошо адгезируют к поверхности материала, покрытого коллагеновым гелем. Исследованы остеоиндуктивные свойства материала с помощью оценки удельной активности щелочной фосфатазы и выявления экспрессии остеокальцина.

Keywords

остеопластика, костный мозг, биосовместимость, жизнеспособность, остеозамещающие материалы

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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