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Эффекты Ð¼Ð¾Ð»ÐµÐºÑƒÐ»ÑÑ€Ð½Ñ‹Ñ Ñ„Ð¾Ñ‚Ð¾Ð¿ÐµÑ€ÐµÐºÐ»ÑŽÑ‡Ð°Ñ‚ÐµÐ»ÐµÐ¹ на дегенирированную сетчатку амфибий

выпускная квалификационная работа магистра
descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2018 Russian Publisher:Санкт-Петербургский политехнический университет Петра Великого

doi: 10.18720/spbpu/2/v18-5205

Эффекты Ð¼Ð¾Ð»ÐµÐºÑƒÐ»ÑÑ€Ð½Ñ‹Ñ Ñ„Ð¾Ñ‚Ð¾Ð¿ÐµÑ€ÐµÐºÐ»ÑŽÑ‡Ð°Ñ‚ÐµÐ»ÐµÐ¹ на дегенирированную сетчатку амфибий

Abstract

В данной работе описано получение простых моделей фоторецепторной дегенерации сетчатки для скрининга синтезированных молекулярных фотопереключателей, которые в перспективе могли бы применяться для протезирования утраченного зрения. Было предложено два варианта: модель с механическим удалением слоя фоторецепторов и модель дегенерации, вызванной действием антибиотика туникамицина. Также на основе предложенных моделей был проведен первичный скрининг нескольких новосинтезированных фотопереключателей, и было показано, что они не способны влиять на светочувствительность сетчатки с фоторецепторной дегенерацией.

Keywords

фотопереключатели, оптофармакология, дегенерация сетчатки, фоторецепторы, электроретинография

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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