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Характеристика уровня и спектра ингибирующей активности Ð¿Ñ€Ð¾Ð¸Ð·Ð²Ð¾Ð´Ð½Ñ‹Ñ [2.2.1]-бициклогептана в отношении вируса гриппа

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Характеристика уровня и спектра ингибирующей активности Ð¿Ñ€Ð¾Ð¸Ð·Ð²Ð¾Ð´Ð½Ñ‹Ñ [2.2.1]-бициклогептана в отношении вируса гриппа

Abstract

Цель работы: определение противовирусной активности в отношении вируса гриппа и токсичности Ð¿Ñ€Ð¾Ð¸Ð·Ð²Ð¾Ð´Ð½Ñ‹Ñ [2.2.1]-бициклогептана. Ð’ дипломной работе проводится анализ 12 Ñ Ð¸Ð¼Ð¸Ñ‡ÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ для определения эффективности Ð¸Ñ Ð¿Ñ€Ð¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ против вируса гриппа, далее проводиться определение токсичности препаратов в отношении культуры клеток. Проведены анализ Ñ Ð¸Ð¼Ð¸Ñ‡ÐµÑÐºÐ¸Ñ ÑÑ‚Ñ€ÑƒÐºÑ‚ÑƒÑ€ соединений и определение влияния ÑÑ‚Ñ€ÑƒÐºÑ‚ÑƒÑ€Ð½Ñ‹Ñ Ñ„Ð¾Ñ€Ð¼ÑƒÐ» на уровень активности и токсичности. Проведенные исследования высоко актуальны в данный момент, выполнен анализ Ð»Ð¸Ñ‚ÐµÑ€Ð°Ñ‚ÑƒÑ€Ð½Ñ‹Ñ Ð´Ð°Ð½Ð½Ñ‹Ñ , представляющий важность проблемы поиска Ð½Ð¾Ð²Ñ‹Ñ Ñ Ð¸Ð¼Ð¸Ñ‡ÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ñ‹Ñ Ðº эффективной противовирусной работе.

Objective: to determine the antiviral activity against influenza virus and the toxicity of the derivatives [2.2.1] -bicycloheptane.The research paper analyzes the 12 chemical compounds to determine their work against the flu virus, then held the definition of drug toxicity in relation to cell culture. The analysis of chemical structures and determining the effect of the compounds of structural formulas the level of activity and toxicity. The research is highly relevant at this time, the analysis of the literature data, representing the importance of the problem of finding new chemical compounds capable of effective antiviral use.

Keywords

A/Aichi/2/68, MTT assay, hemagglutination reaction, A/Puerto Rico/8/34, chemotherapeutic index, МТТ-тест, вирус гриппа, реакция гемагглютинации, influenza virus, Ñ Ð¸Ð¼Ð¸Ð¾Ñ‚ÐµÑ€Ð°Ð¿ÐµÐ²Ñ‚Ð¸Ñ‡ÐµÑÐºÐ¸Ð¹ индекс

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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