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Функциональная роль сигма 1 рецептора генетической модели болезни Хантингтона

специальность 03.01.03 «Молекулярная биология»
descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2021 Russian Publisher:Санкт-Петербургский политехнический университет Петра Великого

doi: 10.18720/spbpu/2/r21-17

Функциональная роль сигма 1 рецептора генетической модели болезни Хантингтона

Abstract

Ð’ работе выяснена функциональная роль сигма 1 рецептора на генетической модели болезни Хантингтона. Предложены модификации оригинального протокола, позволяющие значительно повысить эффективность прямого репрограммирования Ð¿ÐµÑ€Ð²Ð¸Ñ‡Ð½Ñ‹Ñ Ð´ÐµÑ€Ð¼Ð°Ð»ÑŒÐ½Ñ‹Ñ Ñ„Ð¸Ð±Ñ€Ð¾Ð±Ð»Ð°ÑÑ‚Ð¾Ð² в средние шипиковые нейроны стриатума. Оптимизированный протокол полезен при изучении возраст-Ð°ÑÑÐ¾Ñ†Ð¸Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð½Ñ‹Ñ Ð¼Ð¾Ð»ÐµÐºÑƒÐ»ÑÑ€Ð½Ð¾-ÐºÐ»ÐµÑ‚Ð¾Ñ‡Ð½Ñ‹Ñ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ в ÑÑ€ÐµÐ´Ð½Ð¸Ñ ÑˆÐ¸Ð¿Ð¸ÐºÐ¾Ð²Ñ‹Ñ Ð½ÐµÐ¹Ñ€Ð¾Ð½Ð°Ñ Ð¿Ñ€Ð¸ изучении патогенеза болезни Хантингтона.

Keywords

нервная система, Кальций, генетические заболевания, болезнь Хантингтона, Нейроны, нейродегенеративные заболевания

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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