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Динамика Ð¼ÐµÐ¼Ð±Ñ€Ð°Ð½Ð½Ñ‹Ñ Ñ‚Ð¾ÐºÐ¾Ð² и потенциалов, Ð¸Ð½Ð´ÑƒÑ†Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð½Ñ‹Ñ ÑÐ²ÐµÑ‚Ð¾Ð¼ в Ð¿Ð¸Ñ€Ð°Ð¼Ð¸Ð´Ð°Ð»ÑŒÐ½Ñ‹Ñ Ð½ÐµÐ¹Ñ€Ð¾Ð½Ð°Ñ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° мыши

автореф. дис. … канд. физ.-мат. наук: 03.01.02
descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2018 Russian Publisher:Санкт-Петербургский политехнический университет Петра Великого

doi: 10.18720/spbpu/2/r18-73

Динамика Ð¼ÐµÐ¼Ð±Ñ€Ð°Ð½Ð½Ñ‹Ñ Ñ‚Ð¾ÐºÐ¾Ð² и потенциалов, Ð¸Ð½Ð´ÑƒÑ†Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð½Ñ‹Ñ ÑÐ²ÐµÑ‚Ð¾Ð¼ в Ð¿Ð¸Ñ€Ð°Ð¼Ð¸Ð´Ð°Ð»ÑŒÐ½Ñ‹Ñ Ð½ÐµÐ¹Ñ€Ð¾Ð½Ð°Ñ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° мыши

Abstract

Светочувствительные ионные каналы, в частности, каналродопсин-2, являются перспективным инструментом модуляции нейронной активности. Ð’ настоящее время они широко используются в Ð½ÐµÐ¹Ñ€Ð¾Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ‡ÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ , а также имеют перспективы использования для лечения и профилактики Ð½ÐµÐ¹Ñ€Ð¾Ð´ÐµÐ³ÐµÐ½ÐµÑ€Ð°Ñ‚Ð¸Ð²Ð½Ñ‹Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. Использование ÑÐ²ÐµÑ‚Ð¾Ñ‡ÑƒÐ²ÑÑ‚Ð²Ð¸Ñ‚ÐµÐ»ÑŒÐ½Ñ‹Ñ Ð¸Ð¾Ð½Ð½Ñ‹Ñ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² в ÑÐºÑÐ¿ÐµÑ€Ð¸Ð¼ÐµÐ½Ñ‚Ð°Ñ invitro и exvivo, как правило предполагает кратковременную световую стимуляцию, что предотвращает нагрев тканей и позволяет точно контролировать “клеточный ответ”. Однако в invivo ÑÐºÑÐ¿ÐµÑ€Ð¸Ð¼ÐµÐ½Ñ‚Ð°Ñ ÑÐ¸Ñ‚ÑƒÐ°Ñ†Ð¸Ñ складывается иначе. Ð’ диссертации Ð¾Ñ Ð°Ñ€Ð°ÐºÑ‚ÐµÑ€Ð¸Ð·Ð¾Ð²Ð°Ð½Ñ‹ параметры светового стимула, при ÐºÐ¾Ñ‚Ð¾Ñ€Ñ‹Ñ ÑÐ»ÐµÐºÑ‚Ñ€Ð¾Ñ„Ð¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ‡ÐµÑÐºÐ¸Ð¸Ì† ответ Ð¿Ð¸Ñ€Ð°Ð¼Ð¸Ð´Ð½Ñ‹Ñ Ð½ÐµÐ¸Ì†Ñ€Ð¾Ð½Ð¾Ð² гиппокампа мыши, ÑÐºÑÐ¿Ñ€ÐµÑÑÐ¸Ñ€ÑƒÑŽÑ‰Ð¸Ñ ÐºÐ°Ð½Ð°Ð»Ð¾Ñ€Ð¾Ð´Ð¾Ð¿ÑÐ¸Ð½-2, в Ñ Ð¾Ð´Ðµ длительного светового воздействия будет стабильным.

Keywords

Молекулярная биология, Нейроны, Биофизика, нейробиология

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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