Dendritic cells (DCs) are a heterogeneous population of antigen presenting cells(APCs) that initiate and orient immune responses. They sense the pathogens and pathogen-derived antigenic molecules via pattern recognition receptors(PRRs). They process and present extracellular antigens in the context of major histocompatibility complex (MHC) class II molecules to CD4+ T helper cells and intracellular antigens via MHC class I molecules to CD8+ T cells. DCs can also process and present extracellular antigens on MHC class I via the process of cross-presentation. Two main intracellular pathways for cross-presentation have been reported: cytosolic and vacuolar [1].