MiR-195 suppresses non-small cell lung cancer by targeting CHEK1
Copyright policy )MiR-195 suppresses non-small cell lung cancer by targeting CHEK1
MiR-195 suppresses tumor growth and is associated with better survival outcomes in several malignancies including non-small cell lung cancer (NSCLC). Our previous study showed high miR-195 plasma levels associated with favorable overall survival of non-smoking women with lung adenocarcinoma. To further elucidate role of miR-195 in NSCLC, we conducted in vitro experiment as well as clinical studies in a cohort of 299 NSCLC samples. We demonstrated that miR-195 expression was lower in tumor tissues and was associated with poor survival outcome. Overexpression of miR-195 suppressed tumor cell growth, migration and invasion. We discovered that CHEK1 was a direct target of miR-195, which decreased CHEK1 expression in lung cancer cells. High expression of CHEK1 in lung tumors was associated with poor overall survival. Our results suggest that miR-195 suppresses NSCLC and predicts lung cancer prognosis.
- University of Hawaii System United States
- Shanghai Jiao Tong University China (People's Republic of)
- University of Hawaii Cancer Center United States
- Tianjin Medical University Cancer Institute and Hospital China (People's Republic of)
Adult, Aged, 80 and over, Lung Neoplasms, Down-Regulation, Cell Cycle Checkpoints, Kaplan-Meier Estimate, Adenocarcinoma, Gene Expression Regulation, Neoplastic, Cell Movement, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cyclins, Checkpoint Kinase 1, Carcinoma, Squamous Cell, Humans, Female, 3' Untranslated Regions, Cell Division, Aged, Follow-Up Studies
Adult, Aged, 80 and over, Lung Neoplasms, Down-Regulation, Cell Cycle Checkpoints, Kaplan-Meier Estimate, Adenocarcinoma, Gene Expression Regulation, Neoplastic, Cell Movement, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cyclins, Checkpoint Kinase 1, Carcinoma, Squamous Cell, Humans, Female, 3' Untranslated Regions, Cell Division, Aged, Follow-Up Studies
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