Higher platelet distribution width predicts poor prognosis in laryngeal cancer
Copyright policy )Higher platelet distribution width predicts poor prognosis in laryngeal cancer
Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer.Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001).The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW.Elevated PDW might be a novel prognostic marker in laryngeal cancer.
- Third Affiliated Hospital of Harbin Medical University China (People's Republic of)
- Harbin Medical University China (People's Republic of)
- Heilongjiang Academy of Sciences China (People's Republic of)
- Academy of Medical Sciences United Kingdom
- The University of Texas Southwestern Medical Center United States
Male, Platelet Count, Kaplan-Meier Estimate, Middle Aged, Prognosis, ROC Curve, Humans, Female, Neoplasm Grading, Neoplasm Metastasis, Laryngeal Neoplasms, Mean Platelet Volume, Biomarkers, Research Paper, Aged, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies
Male, Platelet Count, Kaplan-Meier Estimate, Middle Aged, Prognosis, ROC Curve, Humans, Female, Neoplasm Grading, Neoplasm Metastasis, Laryngeal Neoplasms, Mean Platelet Volume, Biomarkers, Research Paper, Aged, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies
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