p63 transcriptionally regulates the expression of matrix metallopeptidase 13
Copyright policy )p63 transcriptionally regulates the expression of matrix metallopeptidase 13
p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Here we show that p63 transcriptionally controls the expression of the matrix metallopeptidase 13 (MMP13). p63 binds a p53-like responsive element in the human promoter of MMP13, thus promoting the activation of its transcription. The catalytic activity of MMP13 is required in high invasion capacity of metastatic cancer cells, however, although p63 and MMP13 expression correlates in cancer patients, their co-expression does not predict cancer patient survival. Our results demonstrate that p63 directly controls MMP13 expression.
- Medical Research Council United Kingdom
- University of Leicester United Kingdom
- University of Rome Tor Vergata Italy
- St. Petersburg State Technological Institute Russian Federation
- Saint Petersburg State Forest Technical University Russian Federation
Transcription, Genetic, Transcription Factor, Messenger, Breast Neoplasms, Kaplan-Meier Estimate, p63, MMP13, Collagenase, skin, metastasis, Breast Neoplasms; Cell Line; Humans; Kaplan-Meier Estimate; Matrix Metalloproteinase 13; Melanoma; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Gene Expression Regulation; Transcription, Genetic, Cell Line, Promoter Regions, Genetic, Matrix Metalloproteinase 13, Humans, RNA, Messenger, Promoter Regions, Genetic, Settore BIO/10 - BIOCHIMICA, Melanoma, Oligonucleotide Array Sequence Analysis, info:eu-repo/classification/ddc/570, Tumor Suppressor Protein, Oligonucleotide Array Sequence Analysi, Tumor Suppressor Proteins, Gene Expression Regulation, RNA, Transcription, Breast Neoplasm, Human, Transcription Factors
Transcription, Genetic, Transcription Factor, Messenger, Breast Neoplasms, Kaplan-Meier Estimate, p63, MMP13, Collagenase, skin, metastasis, Breast Neoplasms; Cell Line; Humans; Kaplan-Meier Estimate; Matrix Metalloproteinase 13; Melanoma; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Gene Expression Regulation; Transcription, Genetic, Cell Line, Promoter Regions, Genetic, Matrix Metalloproteinase 13, Humans, RNA, Messenger, Promoter Regions, Genetic, Settore BIO/10 - BIOCHIMICA, Melanoma, Oligonucleotide Array Sequence Analysis, info:eu-repo/classification/ddc/570, Tumor Suppressor Protein, Oligonucleotide Array Sequence Analysi, Tumor Suppressor Proteins, Gene Expression Regulation, RNA, Transcription, Breast Neoplasm, Human, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!