Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells
Copyright policy )Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells
Cancer cells actively release exosomes carrying specific cellular components, such as proteins, mRNA, and miRNA, to communicate with various cells in the tumor microenvironment. We visualized exosome-mediated transfer of miR-210 from hypoxic breast cancer cells to neighboring cells using a miR-210 specific reporter system. By in vitro and in vivo visualization, we found that exosomes with miR-210 were transferred to cells in the tumor microenvironment and that miR-210 was involved in expression of vascular remodeling related genes, such as Ephrin A3 and PTP1B, to promote angiogenesis. These results indicate that cellular components, such as miRNAs from hypoxic cancer cells, spread to adjacent cancer cells in the tumor microenvironment via exosomes and influence tumor progression.
- University of Seoul Korea (Republic of)
- New Generation University College Ethiopia
- Seoul National University Korea (Republic of)
- Cancer Research Institute Slovakia
- Stanford University United States
Male, Mice, Inbred BALB C, Microscopy, Confocal, Green Fluorescent Proteins, Mice, Nude, Biological Transport, Breast Neoplasms, 3T3 Cells, Deferoxamine, Exosomes, Ephrin-A3, Gene Expression Regulation, Neoplastic, Luminescent Proteins, Mice, MicroRNAs, Genes, Reporter, Cell Line, Tumor, Animals, Female, Luciferases, Research Paper
Male, Mice, Inbred BALB C, Microscopy, Confocal, Green Fluorescent Proteins, Mice, Nude, Biological Transport, Breast Neoplasms, 3T3 Cells, Deferoxamine, Exosomes, Ephrin-A3, Gene Expression Regulation, Neoplastic, Luminescent Proteins, Mice, MicroRNAs, Genes, Reporter, Cell Line, Tumor, Animals, Female, Luciferases, Research Paper
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