Transcriptional repression of FOXO1 by KLF4 contributes to glioma progression
Copyright policy )Transcriptional repression of FOXO1 by KLF4 contributes to glioma progression
In this study, our findings indicated that FOXO1 expression frequently decreased in glioma tissues and cells. FOXO1 expression decrease correlated with glioma progression and predicted a worse overall survival of glioma patients. Restored FOXO1 expression inhibited glioma cells invasion and suppressed glioma cells proliferation in vitro and growth in vivo. Additionally, we found that KLF4 expression frequently increased in glioma tissues and negatively correlated with FOXO1 expression. Bioinformatics analysis and experimental results indicated that KLF4 transcriptionally repressed FOXO1 expression in glioma cells. Moreover, KLF4 expression increase correlated with glioma progression and predicted a poorer overall survival of glioma patients. KLF4 knockdown attenuated glioma cells invasion and growth. These data provide a rationale for targeted intervention on KLF4-FOXO1 signaling pathway to suppress glioma progression.
- Central South University China (People's Republic of)
Adult, Male, Mice, Inbred BALB C, Brain Neoplasms, Forkhead Box Protein O1, Kruppel-Like Transcription Factors, Computational Biology, Down-Regulation, Mice, Nude, Glioma, Kaplan-Meier Estimate, Middle Aged, Gene Expression Regulation, Neoplastic, Kruppel-Like Factor 4, Cell Movement, Cell Line, Tumor, Animals, Humans, Female, Research Paper, Cell Proliferation
Adult, Male, Mice, Inbred BALB C, Brain Neoplasms, Forkhead Box Protein O1, Kruppel-Like Transcription Factors, Computational Biology, Down-Regulation, Mice, Nude, Glioma, Kaplan-Meier Estimate, Middle Aged, Gene Expression Regulation, Neoplastic, Kruppel-Like Factor 4, Cell Movement, Cell Line, Tumor, Animals, Humans, Female, Research Paper, Cell Proliferation
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