SIRT2 in age-related neurodegenerative disorders

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 03 Mar 2018 Germany, Spain, Spain English Publisher:Impact Journals, LLCJournal:Aging, volume 10, pages 295-296 (eissn: 1945-4589,

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Authors: Fourcade, Stéphane; Outeiro, Tiago F.; Pujol Onofre, Aurora;

doi: 10.18632/aging.101397

pmid: 29514133

pmc: PMC5892690

handle: 2445/172608

SIRT2 in age-related neurodegenerative disorders

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Abstract

Sirtuin 2 (SIRT2) is one of seven members of the NAD+-dependent histone deacetylases (HDAC) family of proteins. Sirtuins play diverse roles in cellular metabolism and the aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria, is highly expressed in the central nervous system (CNS), and has been reported to regulate a variety of processes including oxidative stress, genome integrity, and myelination [1].

Countries

Germany, Spain, Spain

Related Organizations

University of Göttingen
Germany
Newcastle University
United Kingdom
Max Planck Society
Germany
Institut d'Investigació Biomédica de Bellvitge
Spain
Max Planck Institute for Multidisciplinary Sciences
Germany

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Keywords

Aging, Malalties neurodegeneratives, Neurodegenerative diseases, Neurodegenerative Diseases, Mice, Editorial, Sirtuin 2, Gene Expression Regulation, Envelliment, Animals, Humans, Genetic Predisposition to Disease

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