An epigenetic aging clock for dogs and wolves
Copyright policy )An epigenetic aging clock for dogs and wolves
Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-methylation data from 46 domesticated dogs (Canis familiaris) and 62 wild gray wolves (C. lupus). By regressing chronological dog age on the resulting CpGs, we defined highly accurate multivariate age estimators for dogs (based on 41 CpGs), wolves (67 CpGs), and both combined (115 CpGs). Age related DNA methylation changes in canids implicate similar gene ontology categories as those observed in humans suggesting an evolutionarily conserved mechanism underlying age-related DNA methylation in mammals.
- UNIVERSITY OF CALIFORNIA United States
- University of California United States
- College of New Jersey United States
- University of California United States
- University of California, Los Angeles United States
Male, Aging, DNA methylation, Wolves, Human Genome, 590, canine, Clinical sciences, Biological Sciences, DNA Methylation, biological age, Epigenesis, Genetic, wolf, Dogs, Genetic, Biochemistry and cell biology, dog, Genetics, Animals, Female, epigenetic clock, Epigenesis, Research Paper
Male, Aging, DNA methylation, Wolves, Human Genome, 590, canine, Clinical sciences, Biological Sciences, DNA Methylation, biological age, Epigenesis, Genetic, wolf, Dogs, Genetic, Biochemistry and cell biology, dog, Genetics, Animals, Female, epigenetic clock, Epigenesis, Research Paper
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