In this work, an extract of the Tamarix hispida (TH-10) was prepared in 10 vol.% water-ethanol solution. Based on the properties of antioxidant, and anti-inflammatory activity, various gelatin films containing (10–15 wt.%) gelatin were obtained. The fabricated gelatin films containing TH-10 extract were used as wound dressings for burns. Their deformation properties, physical and mechanical properties, and SEM micrographs were defined. An additional film structure was determined by using a Fourier transform infrared spectrometer (FT-IR). The strength of polymer films containing TH-10 depends on gelatin content. This indicates that the gelatin film binds the TH-10 with the help of hydrophobic interactions. It was found that the higher amount of gelatin leads to lower tear resistance of films. This is due to the formation of micro-cracks on the surface of films leading to their easy rupture. During the study of tensile strength, it was proven that the optimal amount of glycerin in the film is 5 vol.%. The polymer film containing 12 wt.% gelatin and 1 wt.% TH-10 was recognized as the most effective composition in terms of strength and elasticity properties for application as wound dressing materials.