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Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales
Article . 2023 . Peer-reviewed
License: CC BY
Data sources: Crossref
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APROXIMACIÓN IN SILICO A LA ESTRUCTURA 3D DE LA PROTEÍNA ANTIVENENO DM64 DE LA ZARIGÜEYA (MAMMALIA: MARSUPIALIA: DIDELPHIDAE)

Authors: Juan-Fernando Duque-Osorio; Adalberto Sánchez; Leonardo Fierro; Rafael Santiago Castaño;

APROXIMACIÓN IN SILICO A LA ESTRUCTURA 3D DE LA PROTEÍNA ANTIVENENO DM64 DE LA ZARIGÜEYA (MAMMALIA: MARSUPIALIA: DIDELPHIDAE)

Abstract

Los accidentes por mordeduras de serpientes venenosas producen más de 50 mil muertes al año, particularmente en los trópicos donde se han convertido en un problema de salud pública. Estos accidentes producen, entre otros síntomas, hemorragias (SVMPs), mionecrosis (PLAs) y dolor, y las seroterapias convencionales son solo parcialmente efectivas y pueden producir efectos inmunes adversos. Por todo esto, recientemente se están investigando proteínas antiveneno naturales de mamíferos [DM43 (antihemorragina) y DM64 (antimiotóxica) de la zarigüeya] que han demostrado ser más efectivas. Adicionalmente las SVMPs y PLAs venosas tienen sus contrapartes endógenas normales no venenosas (MMPs y PLAs), y cuando el balance entre estas últimas y sus inhibidores se rompe, se producen patologías como: artritis, arterioesclerosis, asma, diabetes, choques sépticos, neoplasias, inflamaciones, psoriasis, reumatismo, etc. Por todo esto se hizo una aproximación in silico y por homología a la estructura 3D de DM64, con el sistema Swiss Model-Deep View. Además de obtener un modelo similar al previamente logrado por otro grupo para DM43, este proceso permitió estandarizar esta técnica de modelamiento de proteínas como una herramienta muy útil en nuestro medio por su eficiencia y bajo costo (SM-DV se puede utilizar gratuitamente).

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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