Background: Laparoscopic cholecystectomy has promptly emerged as a popular alternative to traditional open laparotomy and cholecystectomy. The Objective of the current meta-analysis is to evaluate the effect of Laparoscopic versus open cholecystectomy.Methods: We conducted this meta-analysis using a comprehensive search of Cochrane database of systematic reviews, PubMed, Medline, EMBASE, and Cochrane central register of controlled trials till 15 March 2018 for studies that evaluated laparoscopic versus open cholecystectomy.Results: Eleven studies have been included with a total of 80691 patients: 41485 in the laparoscopic and 39206 into the open cholecystectomy groups. Odds ratios were regularly on the side of laparoscopic operation, in terms of respiratory complications (OR=0.32, 95%CI: 0.34-2.64, p<0.0001), mortality (OR=0.19, 95%CI: 0.08-1.05, p<0.0001), and morbidity (OR=0.31, 95%CI: 0.11-0.45, p<0.0001).Conclusions: Using laparoscopic cholecystectomy decreased morbidity, mortality, and respiratory complications rates. Large-scale and long-term randomized controlled trials in various populations must be carried out in future studies to deliver more significant evidence.