Background: All suture materials are treated as foreign bodies and bring out a reaction in the tissues. The severity and duration of response depends on the type of suture material used. The choice of suture material is based on the concept that it should provide adequate tensile strength across the wound until tissue tensile strength has adequately developed, approximation of the epithelial portion has occurred and that the suture material should be absorbed after serving its function. this study was done to compare irradiated polyglactin 910 (Vicryl Rapide) versus polyglactin 910 (Vicryl) for subcuticular skin closure in patients of elective surgeries and to note post-operative wound inflammation, pain, dehiscence and quality of scar.Methods: 60 consecutive patients undergoing elective surgeries in department of surgery SGRD hospital were taken up for the study from April 2020 to June 2020. After randomization the subjects were divided into two groups. Subcuticular skin closure at the end of surgery was done using a 3-0 polyglactin 910 in group A and 3-0 irradiated polyglactin 910 in group B with cutting needle in both groups. Postoperatively the wound was inspected on day 3, 5, 7 and again 3 weeks after surgery.Results: Postoperatively the wounds were observed for the signs of inflammation and infection. Each was given a wound score according to scoring system. Statistical analysis by SPSS 17.0 software and chi-square test. Irradiated polyglactin 910 showed less inflammation, pain and dehiscence along with good quality of scar as compared to polyglactin 910 on comparison.Conclusions: It was concluded that irradiated polyglactin 910 was a better choice for suture material than polyglactin 910 for subcuticular skin closure in terms of postoperative pain, wound dehiscence and quality of scar.