Introduction: All governments, regardless of available resources, should move to establish a balance between the conflict of resource scarcity of health system and health care services required. This study applied a multi criteria decision analysis (MCDA) approach to contribute to priority-setting and the coverage decision-making on including uninsured orthopedics interventions in the healthcare transformation plan’s subsidized in Iran during year 2015. Methods: This study was conducted in four phases: a comprehensive review of studies related to the methods and criteria for prioritizing health services, identifying prioritization criteria, scoring and finalizing them, weighting of the criteria identified, and planning for a prioritized uninsured coverage for orthopedics intervention. Results: After screening the retrieved titles via PRISMA, from 350 papers, 12 studies were included. The main criteria used for the priority step in the health sector were as follows: safety, efficacy, need, existence of alternative procedures, life expectancy impact, cost, cost-effectiveness, catastrophic health expenditure, impact on the budget, acceptance of social/economic and equity in access. According to the viewpoint of the experts, the safety criteria had maximum weight (0.4) and equity in access had the least weight (0.03). Finally, ten uninsured orthopedics services were prioritized with a score of 9.01 to 5.01. Conclusions: This practical and real-life project significantly contributed to rational, apparent, and unbiased priority-setting practice by using the MCDA methodology. Prioritizing and weighting the criteria in this study indicated that the Iranian policymakers should pay more attention to clinical aspects and benefits of the service than financial issues. This could indicate that there are social perspective and health as the public right in the country.