A one-arm prospective clinical study undertaken in the spring of 2012 in the Department of Graduate Prosthodontics aimed to document the treatment efficacy, fabrication and maintenance requirements, and change in patient quality of life with a 4-implant supported fixed prostheses for the edentulous maxilla. Four endosseous implants 6-8mm in length allowed patients previously confined to complete dentures or overdentures to enjoy the comfort and confidence of a fixed, esthetic dental prosthesis. The study sought to espouse a consistently minimally-invasive approach to implant therapy and provide patients with a specific CAD/CAM zirconia prosthetic design. The manuscripts that follow represent two distinct objectives and outcomes of this unique healthcare intervention: to describe the biological, technical and clinical complications of this treatment modality, and to assess oral health-related quality of life before and after treatment.