This study aims to provide a comprehensive understanding of various types of Intermolecular forces and their influence on the physical and chemical properties of compounds. The primary focus includes Hydrogen bonding, Dipole-dipole forces, and London dispersion forces, as well as their correlation with boiling point, melting point, solubility, and molecular stability. Understanding these intermolecular forces is crucial because they govern many phenomena in Chemistry, Biochemistry, and Materials science, such as solvation behavior, membrane formation, and molecular interactions in biological systems. The method used in this study was a literature review of reputable scientific sources, collecting previously reported experimental data, optimized molecular structures from Density Functional Theory (DFT) calculations, molecular energy diagrams, and characterization data from Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and Ultraviolet–visible spectroscopy (UV-Vis). This approach allowed an in-depth analysis of the relationship between molecular structure and the strength of intermolecular forces. The results indicate that intermolecular forces significantly affect the physical properties of substances, such as the high boiling point of H2O due to strong hydrogen bonding and the low boiling point of I2 due to weak dispersion forces. In conclusion, understanding intermolecular forces is essential to explain the behavior of substances under different conditions and to serve as a basis for designing new materials and compounds.