Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 26 Jan 2018Publisher:Peertechz Publications Private LimitedJournal:Annals of Antivirals and Antiretrovirals

Authors: Qadir Muhammad Imran;

doi: 10.17352/aaa.000003

Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach

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Abstract

Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions. Its binding energy after modification (Thiolutin1) was -6.7 kcal/mol, which was greater than the original thiolutin affinity.

Related Organizations

Bahauddin Zakariya University
Pakistan

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