Objectives: Analyzing environmental risk five sampling stations on the Cauca, due to the presence of phenol, previously detected, especially on the basis of some of the alkyl phenols found at risk of endocrine disruption in mammals including man. Scope: Qualitative chemical inventory of water collected and analyzed. Methodology: The technique of gas chromatography coupled to mass spectrometry was applied to identify your risk may, with the support of databases: Pubmed Compounds, Chem Pubmed, Science Direct, IARC –International Agency of Research on Cancer– and Leaves of Security –MSDS–. Main results: 70 organic compounds, among which are some alkyl phenols, some of which pose a risk to human health and aquatic ecosystems, others are without risk characterization and a last group without information were identified. Conclusions: It is a pioneering work to understand the risks of urban, agricultural and industrial pollution of the river, passing through the city of Cali and will be useful for the control entities in the region, such as the Regional Autonomous Corporation of Valley Cauca, CVC, may take the measures necessary for the proper management of the river.