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Cell Differentiation and Checkpoint

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2015Publisher:Sci Forschen, Inc.Journal:International Journal of Cancer Research and Molecular Mechanisms ( ISSN 2381-3318 ), volume 1 (eissn: 2381-3318,

Copyright policy )Funded by:NIH | ROSWELL PARK MEMORIAL INS..., NIH | Roswell Park Cancer Insti..., NIH | BRCA1 function in G2-M c... +1 projects

Authors: Sara Cuesta Sancho; Toru Ouchi;

doi: 10.16966/2381-3318.107

pmid: 26998525

pmc: PMC4795824

Cell Differentiation and Checkpoint

- Summary
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Abstract

DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation. Among these programs is cell cycle checkpoint that ensures cell cycle arrest and subsequent repair of the damaged DNA, apoptosis and senescence in various phases of the cell cycle. Moreover, recent studies have established the cell differentiation checkpoint, the other type of the checkpoint that is specifically activated in the course of differentiation. We will discuss the evidences that support the link between DNA damage proteins and C2C12 cell differentiation.

Related Organizations

Roswell Park Cancer Institute
United States

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average