
doi: 10.1691/ph.2011.0185
pmid: 21553645
The degradation kinetics of olanzapine as a function of pH and temperature has been studied by a spectrophotometric method. The degradation reaction rates were observed to follow first-order kinetics with respect to olanzapine. The hydrolytic reaction was shown to be hydrogen and hydroxide ion-catalyzed and the Arrhenius plots showed the temperature dependence of olanzapine degradation.
Temperature, Water, Reference Standards, Catalysis, Solutions, Benzodiazepines, Kinetics, Drug Stability, Olanzapine, Spectrophotometry, Ultraviolet, Algorithms, Antipsychotic Agents
Temperature, Water, Reference Standards, Catalysis, Solutions, Benzodiazepines, Kinetics, Drug Stability, Olanzapine, Spectrophotometry, Ultraviolet, Algorithms, Antipsychotic Agents
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