Studies of the skin permeation of lipophilic drugs: paclitaxel.

The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.

Related Organizations

National Institute of Pharmaceutical Education and Research
India

Keywords

Ethanol, Paclitaxel, Skin Absorption, In Vitro Techniques, Antineoplastic Agents, Phytogenic, Lipids, Water Loss, Insensible, Permeability, Rats, Rats, Sprague-Dawley, Animals, Diffusion Chambers, Culture, Pharmaceutical Vehicles

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