Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)
Copyright policy )Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)
IL-1R8, also known as SIGIRR or TIR8, is a trans-membrane protein belonging to the IL-1 receptor family. The human gene includes ten exons, and alternative splicing can result in different isoforms. We, herein, characterized a longer isoform of IL-1R8 containing an in-frame additional sequence between the TIR domain and the C-terminal portion of the protein. IL-1R8 Long (IL-1R8L1) mRNA was specifically expressed and regulated in distinct cell lines, in a manner similar to the classic isoform. Overexpression of IL-1R8L1 resulted in the production of a corresponding protein that showed a pattern of cell localization similar to the classic isoform. An antibody directed against an IL-1R8L1 specific peptide, detected this novel isoform in different cell lines and tissues where this protein may complement the anti-inflammatory functions of classic IL-1R8.
Alternative Splicing, Gene Expression Regulation, Fluorescent Antibody Technique, Humans, Protein Isoforms, Receptors, Interleukin-1, RNA, Messenger, Cloning, Molecular, Cell Line, Signal Transduction
Alternative Splicing, Gene Expression Regulation, Fluorescent Antibody Technique, Humans, Protein Isoforms, Receptors, Interleukin-1, RNA, Messenger, Cloning, Molecular, Cell Line, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).12 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!