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Immunogenetics of nasopharyngeal carcinoma

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2014Publisher:JLEJournal:Annales de biologie clinique, volume 72, pages 281-291 (issn: 0003-3898,

Authors: Arij Ben Chaaben; Hayet Douik; Ryad Tamouza; Rajagopal Krishnamoorthy; Fethi Guemira; Dominique Charron; Hajer Abaza; +1 Authors

doi: 10.1684/abc.2014.0958

pmid: 24876139

Immunogenetics of nasopharyngeal carcinoma

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Abstract

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Genetic predisposition linked to the immune system has been associated with various tumors. This involves genetic diversity of the genes encoding the molecules of the immune response such as inflammation and anti-tumor surveillance. In this work, we examined the impact of the immunogenetic diversity on the risk of the NPC in different populations studied. These data show that the interindividual variability of the genetic regulation of immune processes increases the risk of NPC in individuals previously predisposed due to other risk factors (genetic / environmental). This synthesis, in addition to the predictive aspects, could provide innovative research for the development of new therapeutic approaches.

Related Organizations

Institut Salah-Azaïz
Tunisia
French Institute of Health and Medical Research
France

Keywords

Carcinoma, Genes, MHC Class II, Genetic Variation, Nasopharyngeal Neoplasms, Humans, Gene-Environment Interaction, Genetic Predisposition to Disease, Immunogenetic Phenomena, Immunologic Surveillance

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