The factor V deficiency is a very rare hereditary disease of the coagulation, which is accompanied by a high hemorrhagic risk in the event of delivery and in the post-partum. We report the case of a woman having a factor V deficiency which had a pregnancy, and which gave birth by Cesarean, as replacement therapy we proposed the transfusion of 20 mL/kg of fresh frozen plasma before surgery and of 5 mL/kg by 12 h during 7 days in post-partum, this attitude allowed to avoid the hemorrhagic complications.