THE ACTION OF CLOMIPHENE IN THE FERRET
Copyright policy )THE ACTION OF CLOMIPHENE IN THE FERRET
SUMMARY In an attempt to interfere pharmacologically with the feedback action of oestrogen in the ferret, clomiphene citrate was given to anoestrous animals for 10 days, and to oestrous females for 7 or 14 days, in doses ranging from 10 μg to 1000 μg daily. With the higher doses oestrogenic effects on the uterus were observed, while arrest of follicular development in the ovaries indicated inhibition of gonadotrophin secretion. Enhancement of gonadotrophin secretion in anoestrous females was not encountered, although ovulation in oestrous females was an occasional consequence of treatment with the drug.
Body Weight, Carnivora, Ovary, Uterus, Estrogen Antagonists, Genitalia, Female, Organ Size, Clomiphene, Feedback, Vulva, Estrus, Ovarian Follicle, Pregnancy, Adrenal Glands, Animals, Female, Gonadotropins
Body Weight, Carnivora, Ovary, Uterus, Estrogen Antagonists, Genitalia, Female, Organ Size, Clomiphene, Feedback, Vulva, Estrus, Ovarian Follicle, Pregnancy, Adrenal Glands, Animals, Female, Gonadotropins
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