Abstract A 13-year-old female double yellow-headed Amazon parrot (Amazona ochrocephala oratrix) was examined for respiratory distress and partial anorexia. Radiographs, ultrasonography, and computed tomography revealed a soft-tissue opacity in the right cranial coelom with a necrotic or fluid-filled center. Endoscopy was used to visualize the mass, collect diagnostic samples, and treat the patient by cyst ablation and fistula formation. The symptoms returned within weeks after each treatment, and the bird died 36 days after initial presentation. Gross and histopathologic examination revealed the mass was a hemangiosarcoma that was attached to the right internal carotid artery.