The use of procedural sedation in birds has become a routine practice in veterinary medicine during the past 10 years, with a corresponding increase in avian sedation research. Sedation is most often used in a clinical setting for birds to facilitate examination and/or diagnostic sample collection, splint application, grooming, and minor surgical procedures. Sedation provides several benefits over manual restraint or general anesthesia when performing clinical procedures. This review provides an overview of current studies on avian sedation and discusses common indications, protocols, and adverse effects of sedation in avian patients.