Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
Copyright policy )Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.
- University of Toronto Canada
- Hospital for Sick Children Canada
p63, NEDD8, NEDD8 Protein, Ubiquitin, p73, SUMO-1 Protein, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell Transformation, Neoplastic, Gene Expression Regulation, SUMO, ubiquitin, Humans, Tumor Suppressor Protein p53, Ubiquitins, RC254-282
p63, NEDD8, NEDD8 Protein, Ubiquitin, p73, SUMO-1 Protein, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell Transformation, Neoplastic, Gene Expression Regulation, SUMO, ubiquitin, Humans, Tumor Suppressor Protein p53, Ubiquitins, RC254-282
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