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Spectrophotometric determination of cefaclor in pharmaceutical preparations

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1999 Brazil Publisher:FapUNIFESP (SciELO)Journal:Química Nova, volume 22, pages 201-204 (issn: 0100-4042, Copyright policy )
Authors: Ivama, Viviane M.; Rodrigues, Letícia N. C.; Guaratini, Cláudia C. I.; Zanoni, Maria Valnice Boldrin;

doi: 10.1590/s0100-40421999000200011

handle: 11449/25705

Spectrophotometric determination of cefaclor in pharmaceutical preparations

Abstract

A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.

Country
Brazil
Related Organizations
Keywords

Chemistry, hydrolysis, pharmaceuticals, cefaclor, QD1-999

  • BIP!
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    		 19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Average
Green
gold