Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs
Copyright policy )Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs
Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus strains was evaluated. Petri dishes with sub-inhibitory concentrations of EEP were incubated with 13 drugs using Kirby and Bauer method and synergism between EEP and five drugs [choramphenicol (CLO), gentamicin (GEN), netilmicin (NET), tetracycline (TET), and vancomycin (VAN)] was observed. Nine drugs were assayed by the E-test method and five of them exhibited a synergism [CLO, GEN, NET, TET, and clindamycin (CLI)]. The results demonstrated the synergism between EEP and antimicrobial drugs, especially those agents that interfere on bacterial protein synthesis.
- Universidade Estadual Paulista Brazil
- Sao Paulo State University Brazil
- Universidade Estadual Paulista - UNESP Brazil
- University of Toronto Canada
Staphylococcus aureus, 571, Kirby and Bauer method, E-test method, Infectious and parasitic diseases, RC109-216, Microbial Sensitivity Tests, Microbiology, Propolis, newborn, Antimicrobial drugs, Humans, human, Bacteria (microorganisms), drug potentiation, drug effect, Infant, Newborn, Infant, Drug Synergism, antimicrobial drugs, QR1-502, Anti-Bacterial Agents, antiinfective agent, propolis, Staphylococcus aureus - Kirby and Bauer method - E-test method - antimicrobial drugs, microbiological examination, Apoidea
Staphylococcus aureus, 571, Kirby and Bauer method, E-test method, Infectious and parasitic diseases, RC109-216, Microbial Sensitivity Tests, Microbiology, Propolis, newborn, Antimicrobial drugs, Humans, human, Bacteria (microorganisms), drug potentiation, drug effect, Infant, Newborn, Infant, Drug Synergism, antimicrobial drugs, QR1-502, Anti-Bacterial Agents, antiinfective agent, propolis, Staphylococcus aureus - Kirby and Bauer method - E-test method - antimicrobial drugs, microbiological examination, Apoidea
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