In this paper, a new analog signal transmission technique called analog single-carrier transmission with frequency-domain equalization (analog SC-FDE) is proposed. The proposed analog SC-FDE applies discrete Fourier transform (DFT), frequency-domain spectrum shaping and mapping, inverse DFT (IDFT), and cyclic prefix insertion before transmission. At the receiver, one-tap frequency-domain equalization (FDE) is applied to take advantage of the channel frequency-selectivity. As an example, in this paper, the analog voice transmission is considered. By computer simulation, we evaluate the normalized mean square error (NMSE) performance to show that analog SC-FDE achieves better NMSE performance than conventional analog signal transmission scheme.