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Hyperbaric oxygen therapy as an anti-infective agent

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2009 English Publisher:Informa UK LimitedJournal:Expert Review of Anti-infective Therapy, volume 7, pages 1,015-1,026 (issn: 1478-7210, eissn: 1744-8336,

Authors: Guenalp Uzun; Senol Yildiz; Maide Cimsit;

doi: 10.1586/eri.09.76

pmid: 19803709

Hyperbaric oxygen therapy as an anti-infective agent

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Abstract

Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.

Related Organizations

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Keywords

Hyperbaric Oxygenation, Treatment Outcome, Anti-Infective Agents, Mycoses, Surgical Wound Infection, Osteomyelitis, Fasciitis, Necrotizing, Communicable Diseases, Gas Gangrene, Diabetic Foot

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	86
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%